Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora
Identifieur interne : 000737 ( Main/Exploration ); précédent : 000736; suivant : 000738Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora
Auteurs : Jin-Yuan Ho ; Hui-Wen Chang ; Chwan-Fwu Lin ; Chien-Jou Liu ; Chung-Fan Hsieh ; Jim-Tong Horng [Taïwan]Source :
- Viruses [ 1999-4915 ] ; 2014.
Abstract
Bai Shao (BS, the root of
Url:
DOI: 10.3390/v6041861
PubMed: 24762393
PubMed Central: 4014724
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant <italic>Paeonia lactiflora</italic></title><author><name sortKey="Ho, Jin Yuan" sort="Ho, Jin Yuan" uniqKey="Ho J" first="Jin-Yuan" last="Ho">Jin-Yuan Ho</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Chang, Hui Wen" sort="Chang, Hui Wen" uniqKey="Chang H" first="Hui-Wen" last="Chang">Hui-Wen Chang</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Chwan Fwu" sort="Lin, Chwan Fwu" uniqKey="Lin C" first="Chwan-Fwu" last="Lin">Chwan-Fwu Lin</name><affiliation><nlm:aff id="af2-viruses-06-01861">Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan; E-Mail:<email>cflin@gw.cgust.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Liu, Chien Jou" sort="Liu, Chien Jou" uniqKey="Liu C" first="Chien-Jou" last="Liu">Chien-Jou Liu</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Chung Fan" sort="Hsieh, Chung Fan" uniqKey="Hsieh C" first="Chung-Fan" last="Hsieh">Chung-Fan Hsieh</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Horng, Jim Tong" sort="Horng, Jim Tong" uniqKey="Horng J" first="Jim-Tong" last="Horng">Jim-Tong Horng</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-viruses-06-01861">Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333</wicri:regionArea><wicri:noRegion>Taoyuan 333</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-viruses-06-01861">Department of Medical Research, Chang Gung Memorial Hospital, Kweishan, Taoyuan 333, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Chang Gung Memorial Hospital, Kweishan, Taoyuan 333</wicri:regionArea><wicri:noRegion>Taoyuan 333</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24762393</idno><idno type="pmc">4014724</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014724</idno><idno type="RBID">PMC:4014724</idno><idno type="doi">10.3390/v6041861</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000C45</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C45</idno><idno type="wicri:Area/Pmc/Curation">000C45</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C45</idno><idno type="wicri:Area/Pmc/Checkpoint">000524</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000524</idno><idno type="wicri:Area/Ncbi/Merge">000A38</idno><idno type="wicri:Area/Ncbi/Curation">000A38</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A38</idno><idno type="wicri:Area/Main/Merge">000738</idno><idno type="wicri:Area/Main/Curation">000737</idno><idno type="wicri:Area/Main/Exploration">000737</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant <italic>Paeonia lactiflora</italic></title><author><name sortKey="Ho, Jin Yuan" sort="Ho, Jin Yuan" uniqKey="Ho J" first="Jin-Yuan" last="Ho">Jin-Yuan Ho</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Chang, Hui Wen" sort="Chang, Hui Wen" uniqKey="Chang H" first="Hui-Wen" last="Chang">Hui-Wen Chang</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Chwan Fwu" sort="Lin, Chwan Fwu" uniqKey="Lin C" first="Chwan-Fwu" last="Lin">Chwan-Fwu Lin</name><affiliation><nlm:aff id="af2-viruses-06-01861">Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan; E-Mail:<email>cflin@gw.cgust.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Liu, Chien Jou" sort="Liu, Chien Jou" uniqKey="Liu C" first="Chien-Jou" last="Liu">Chien-Jou Liu</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Hsieh, Chung Fan" sort="Hsieh, Chung Fan" uniqKey="Hsieh C" first="Chung-Fan" last="Hsieh">Chung-Fan Hsieh</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation></author><author><name sortKey="Horng, Jim Tong" sort="Horng, Jim Tong" uniqKey="Horng J" first="Jim-Tong" last="Horng">Jim-Tong Horng</name><affiliation><nlm:aff id="af1-viruses-06-01861">Department of Biochemistry, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; E-Mails:<email>jinyuanho@gmail.com</email> (J.-Y.H.);<email>a86x84@hotmail.com</email> (H.-W.C.);<email>b8921043@gmail.com</email> (C.-J.L.);<email>doctordoctorkk@yahoo.com.tw</email> (C.-F.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-viruses-06-01861">Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333</wicri:regionArea><wicri:noRegion>Taoyuan 333</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-viruses-06-01861">Department of Medical Research, Chang Gung Memorial Hospital, Kweishan, Taoyuan 333, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Chang Gung Memorial Hospital, Kweishan, Taoyuan 333</wicri:regionArea><wicri:noRegion>Taoyuan 333</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bai Shao (BS, the root of <italic>Paeonia lactiflora</italic> Pall.), a common Chinese herb in many recipes used to treat viral infection and liver diseases, is recognized for its ability to nourish menstruation, its Yin convergence, and as an antiperspirant. However, the mechanism and components for its antiviral function remain to be elucidated. In this study, an ethanolic extract of BS was further partitioned into aqueous and organic parts (EAex) for <italic>in vitro</italic> functional study and <italic>in vivo</italic> efficacy testing. EAex exhibited an IC<sub>50</sub> of 0.016 ± 0.005 mg/mL against influenza virus A/WSN/33 (H1N1), with broad-spectrum inhibitory activity against different strains of human influenza A viruses, including clinical oseltamivir-resistant isolates and an H1N1pdm strain. The synthesis of both viral RNA and protein was profoundly inhibited when the cells were treated with EAex. A time-of-addition assay demonstrated that EAex exerted its antiviral activity at various stages of the virus replication cycle. We addressed its antiviral activity at virus entry and demonstrated that EAex inhibits viral hemagglutination and viral binding to and penetration into host cells. <italic>In vivo</italic> animal testing showed that 200 mg/kg/d of EAex offered significant protection against viral infection. We conclude that BS possesses antiviral activity and has the potential for development as an anti-influenza agent.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nellore, A" uniqKey="Nellore A">A. Nellore</name></author><author><name sortKey="Fishman, J" uniqKey="Fishman J">J. Fishman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambhara, S" uniqKey="Sambhara S">S. Sambhara</name></author><author><name sortKey="Poland, G A" uniqKey="Poland G">G.A. Poland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R. 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Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, J T" uniqKey="Hsu J">J.T. Hsu</name></author><author><name sortKey="Yeh, J Y" uniqKey="Yeh J">J.Y. Yeh</name></author><author><name sortKey="Lin, T J" uniqKey="Lin T">T.J. Lin</name></author><author><name sortKey="Li, M L" uniqKey="Li M">M.L. Li</name></author><author><name sortKey="Wu, M S" uniqKey="Wu M">M.S. Wu</name></author><author><name sortKey="Hsieh, C F" uniqKey="Hsieh C">C.F. Hsieh</name></author><author><name sortKey="Chou, Y C" uniqKey="Chou Y">Y.C. Chou</name></author><author><name sortKey="Tang, W F" uniqKey="Tang W">W.F. Tang</name></author><author><name sortKey="Lau, K S" uniqKey="Lau K">K.S. Lau</name></author><author><name sortKey="Hung, H C" uniqKey="Hung H">H.C. Hung</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chang, Hui Wen" sort="Chang, Hui Wen" uniqKey="Chang H" first="Hui-Wen" last="Chang">Hui-Wen Chang</name><name sortKey="Ho, Jin Yuan" sort="Ho, Jin Yuan" uniqKey="Ho J" first="Jin-Yuan" last="Ho">Jin-Yuan Ho</name><name sortKey="Hsieh, Chung Fan" sort="Hsieh, Chung Fan" uniqKey="Hsieh C" first="Chung-Fan" last="Hsieh">Chung-Fan Hsieh</name><name sortKey="Lin, Chwan Fwu" sort="Lin, Chwan Fwu" uniqKey="Lin C" first="Chwan-Fwu" last="Lin">Chwan-Fwu Lin</name><name sortKey="Liu, Chien Jou" sort="Liu, Chien Jou" uniqKey="Liu C" first="Chien-Jou" last="Liu">Chien-Jou Liu</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Horng, Jim Tong" sort="Horng, Jim Tong" uniqKey="Horng J" first="Jim-Tong" last="Horng">Jim-Tong Horng</name></noRegion><name sortKey="Horng, Jim Tong" sort="Horng, Jim Tong" uniqKey="Horng J" first="Jim-Tong" last="Horng">Jim-Tong Horng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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